Faculty Research

Synthetic Organic and Organometallic Chemistry; Catalysis

Andrew Duncan, Assistant Professor

Development of chiral organic catalysts derived from 2-amino sugars: simple compounds for tricky tasks.

Ring-closing metathesis reactions of allenes: developing new methods for making synthetically challenging large-ring molecules.

Analytical and Environmental Chemistry

David Goodney, Associate Dean

Instrumental methods for environmental analysis. For example, UV-visible spectroscopy for measurement of pH.

Metal ions in the environment, particularly interactions with living organisms and phytoremediation.

Analysis of antioxidants in wine.

Inorganic, Bioinorganic, and Organometallic Chemistry

Karen Holman, Associate Professor

Ligand exchange reactions of Ru(II) and Ru(III) anti-cancer drugs using infrared spectroelectrochemistry.

X-ray spectroscopic determination of electron distribution in Ru-Cl bonds in ruthenium-based anti-cancer drugs and their derivatives.

Kinetics of short-lived intermediates generated by laser flash photolysis of metal nitrosyl and carbonyl complexes (in collaboration with Prof. Williamson).

Binding and cleavage studies of metal complexes with tRNA (in collaboration with Prof. Kirk).

Organic Chemistry

Tony Hoobler, Visiting Assistant Professor

The effect of steric, through-bond and through-space chlorine-chlorine interactions on the conformational stability of molecules and stereochemical outcomes of reactions.

The factors that influence the formation, structure and fate of the oxaphosphetane intermediate in the Wittig reaction.

The role of chlorine-substituted dienophiles and dienes on the stereochemistry of the Diels-Alder adduct.

The application of Spartan, a molecular mechanical and quantum chemical calculations program, to the theoretical study of reactions under kinetic and thermodynamic control.

Bioorganic Chemistry

Sarah Kirk, Associate Professor

Design and synthesis of novel pharmaceuticals utilizing amino acid-aminoglycoside scaffolds.

Investigation of the binding betewen novel molecules and nucleic acid via fluorescence spectroscopy.

Define essential elements within novel molecules that dictate nucleic acid specificity.

Biochemistry

Todd Silverstein, Professor

How do toxic heavy metal ions inhibit enzymes? (Let me count the ways…)

Enzyme activity in non-aqueous deep eutectic solvents

Photochemistry of sunscreens: Do sunscreen components really protect against photo-induced free radical production?

Degradation of organic pollutants: using UV light and sonication to degrade PCBs, dioxins, antibiotics, and other pollutants

Physical Chemistry

Chuck Williamson , Chair and Associate Professor

Characterization of liquid-liquid coexistence curves by laser light scattering

Assessment of solvent shell structure and microscopic interactions in liquid-liquid mixtures using Raman spectroscopy

Nanosecond time-resolved investigations of fluorescence up-conversion from mixtures of ruthenium compounds and organic molecules

Development of NMR spectroscopy techniques for studying liquid-liquid behavior

Raman spectroelectrochemical investigations of Ru(II) and Ru(III) anti-cancer compounds, (in collaboration with Professor Holman)